Doxycycline

Description

As an anti-bacterial medicine Doxycycline, also known as Vibramycin-D, is used to treat a wide range of infections caused by bacteria. It is commonly used to prevent malaria infection, being one of three anti-malarial drugs used against the P.falciparum parasite for areas of chloroquine-resistant malaria. In some cases it is also used in combination with quinine to treat malaria.

What does it do?

Doxycycline is a suppressive prophylactic and prevents malaria by killing the P.falciparum parasite when it is in the blood stage of its life cycle. Doxycycline must be continued for four weeks after leaving a malarial area.

Who is at risk of malaria?

Malaria is endemic in some tropical and sub-tropical areas. The disease is spread by mosquitoes in infected areas of South America, Southern Asia and Africa. Before travelling to these areas, it is important to check the risk of malaria for the specific location and time of year you are visiting. Consult the NHS Fit for Travel website or contact a travel medicine professional for more advice.

Why doxycycline?

Doxycycline is suitable as a preventative for travel to areas where there is high risk of P.falciparum malaria, with chloroquine resistance. It is prescribed after a medical consultation taking account of individual suitability, side effects, and possible adverse events. Doxycycline can be an attractive option because it is relatively low cost and usually well tolerated.

Taking doxycycline for the first time

All medication should be taken as prescribed. Doxycycline to prevent malaria, is taken at a dose of one 100mg capsule per day for adults and children over 12 (further information about malaria tablets for children). The course should begin two days before travel, continuing throughout exposure to malaria, and then for four weeks afterwards. It is essential that the full course is completed.

Doxycycline should always be taken with food, preferably standing or sitting up, and preferably not just before lying down. It can cause acid reflux symptoms.

How effective is it?

No anti-malarial is 100% effective. It is important to take preventative measures in high-risk areas of malaria, including covering exposed limbs, using an effective insect repellent and using mosquito nets.

Side effects of doxycycline

All medicines have the potential to cause side-effects and reactions in some individuals. A full list of the most frequent side effects can be found in the manufacturer’s patient information leaflet supplied with doxycycline tablets.

Side effects include gastrointestinal problems (such as nausea and diarrhoea), thrush, heartburn and increased light sensitivity that can lead to sunburn.

Photosensitivity and doxycycline

Doxycycline can cause serious skin reactions to sunlight and increases the incidence of sunburn. Avoid direct sunlight and use high-factor sunscreen.

When not to take doxycycline

During a consultation with Dr Fox, you will be asked to complete an online assessment questionnaire to determine your suitability for anti-malarial medication. You should not take doxycycline without further consultation with your GP if you:

  • Are pregnant or breastfeeding, or expect to be during your trip or for 4 weeks after
  • Are under the age of 12
  • Have a sensitivity to tetracycline antibiotics
  • Have liver problems or are taking hepatotoxic medications
  • Have a history of lupus or myasthenia gravis

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